Ozone in Medicine

 

TEN YEAR STUDY IN PATIENTS SUFFERING FROM RETINITIS PIGMENTOSA AND TREATED WITH REPEATED CYCLES OF OZONE THERAPY.

M. Copello, S. Menéndez1, I. Horrach, J. Betancourt.

Retinitis Pigmentosa is an hereditary disease of the retina which produces night blindness, peripheral visual field loss and narrowing of the central vision, which degenerates, after several years, in total blindness. This disease affects approximately 0.5 % of the world population and it is estimated that in Cuba suffer this disease, 3.1 per 10,000 habitants, with a great incidence in the central and west region of the country. In Cuba, it has been using ozone therapy like part of the treatment of Retinitis Pigmentosa, since November 1986, in "Salvador Allende" University Hospital. A study of the clinical evolution of 20 patients that have been treated (between 5 and 10 years) with repetitive cycles of ozone therapy was performed. No other therapy was associated. The ways of ozone application was autohemotherapy or rectal insufflation. A complete ophthalmologic examination was performed during this period. Snellen visual acuity, considering significant changes more than 2 lines and Goldmann kinetic visual field (V-4e target), considering significant changes increase in more than 10 grades and/or appearance of peripheric windows, were analyzed. The best results were achieved when ozone treatment is repeated, at least, twice a year, along all these years, with improvement of 70 % in the visual field and 42 % in the visual acuity. The rest of the patients maintained their visual field or visual acuity the same as the initial value, without worsen the disease. Any side effect was observed. The satisfactory results encourage to recommend its use in patients affected by Retinitis Pigmentosa.

 

CONTROLLED CLINICAL TRIAL ON THE USE OF OZONATED BLOOD AS A TREATMENT FOR RETINITIS PIGMENTOSA.

N. Moreno, O. Peláez, T. Alemán, C. Barceló.

The aim of this study is to determine the effects of ozone as a therapy for patient with retinitis pigmentosa. A double blind, placebo controlled study was designed, in which 123 patients, ages 15 to 65 years, and suffering from typical forms of retinitis pigmentosa participated Sixty two patients were randomly assigned to the treatment group and 61 to the control group. A complete

 

general and ophthalmologic examination was performed after signing an informed consent Snellen visual acuity was measured (less than 2.5 lines considered non significant changes) and Goldmann kinetic visual field with 31.5 asb. background and V-4e target. Visual field areas were digitized and measured with a computer program (VISUAL). Ozonated blood was administered to patients in the treatment group, in a daily fashion for 15 days, while patients in the control group received only blood. Participants were blind with regards to this, throughout the duration of the study Visual acuity remained the same, 6 months after the treatment, in 74.2 % of the patients, improve in 21 % and worsen in 4.8 %. Visual field area remained the same, 6 months after the treatment, in 41.9 % of the patients, improve in 46.7 % and worsen in 11.35 %. Significant differences were observed between groups, with lower frequencies of improvements in controls are larger proportions of worsening. Improvements were not observed in 91.9 % of patients one year after the treatment. This tendency was first noted after 6 months from the treatment. Ozone treatment is proved of benefit in patients with RP, although its action is temporary .Repeated administration after 6 months is recommendable to maintain its action.

 

EFECTS OF OZONE IN PATIENTS WITH RETINITIS PIGMENTOSA.

Y. Mapolon, M. Palma1, E. Resio, M. Rodríguez, E. Dyce1, C. Harrys, J. C. Pina1.

The effects of ozone in 50 patients with retinitis pigmentosa was evaluated in the Retinitis Pigmentosa Center, Camagüey, Cuba. The patients suffer of photophobia, photopsia and reduce vision on dark places. Considering that the patients with remission of two symptoms of the disease after the ozone treatment is considered as signs improvement, in this case all of them after the 7th and 8th ozone application didn't present photophobia and phototopsia, increasing also the quality of their vision (by means of improvement in the visual acuity and visual field). In spite of, after 6 month the appearance of signs and symptoms in all the patients took place. It is considered that the results are important and very useful as alternative in patients that not admit the surgery, repeating it twice a year.

 

OZONE THERAPY IN DIFFERENT OPHTHALMOLOGIC DISEASES.

E. C. Díaz, L.Borrego1, S. Menéndez2, L. R. Borrego3, R. A. Borrego3.

 

Since 1992, we have been using ozone therapy in our province, like a new therapeutic option in the treatment of Retinitis Pigmentosa. Taking into account the different medical properties of ozone: Improvement of the oxygen transportation to tissue, activation of the enzymes participating in peroxide or oxygen radical scavenging, immunological and metabolic modulator, as well as to be a therapy ease to apply, we decided to use ozone therapy in others ophthalmologic diseases. 180 patients were treated with daily rectal ozone therapy, during 20 days, representing 80 with Retinitis Pigmentosa (no systemic, stage I and II), 45 with progressive myopia, 25 with chronic glaucoma of open angle (tonometrically compensated), 20 with optic atrophy (less than one year of evolution and not hereditary), 10 with diabetic retinopathy (no proliferative). Healing criteria was according to each disease. Clinical evaluation was made each 3 months, up to 1 year. In patients with Retinitis Pigmentosa, 75 % improved their visual acuity (post-treatment and 6 months later). After 1 year, 23 % of improvement still remained. According to visual field, 76 % of patients improved it after treatment and up to 9 months, but after 1 year, 16 % lost their improvement. Respect to progressive myopia, the visual acuity increased in 78 % (post-treatment and 9 months later) and remained 58 % after 1 year. In glaucoma, 65 % increased the visual acuity (post-treatment and 9 months later), maintaining 53 % of improvement after 1 year. Visual field increased in 76 % of patients, post-treatment and after 1 year. In diabetic retinopathy, 60 % improved their visual acuity (post-treatment), diminishing to 40 %, 6 months later and 20 %, after 1 year. Respect to optic atrophy, 45 % of improvement in visual field was achieved (post-treatment) maintaining its figure after 1 year. It is concluded that ozone therapy offers very good results in this opthalmologic diseases, without side effects, being necessary to repeat the treatment in dependence of the disease and the patient evolutions.

 

REHABILITATION OF PATIENTS WITH PRIMARY GLAUCOMA OF OPEN ANGLE UNDER SANATORIAL REGIMEN.

L. Ferrer, I. Fernández, M. Ibañez, A. Rodríguez, F. Varela, D. Santos, B. Lazo, R. Marin, I. Jiménez, J.R. Amaro.

Primary glaucoma of open angle is a disease that can invalidate man in different stages of his physical labor and intellectual life. Several studies in various countries, placed it among the world three primary causes of visual blindness invalidity. Studies carried out by Health World Organization in 1992 reported it as the second cause of blindness in Latin America and the first in the Caribbean area. It is a kind of multifactorial disease for which does not exist an unique solution. Therefore, this element has to be taken into account at the time of a medical therapeutic. Ocular hemodynamic changes are an important factor which play a fundamental

 

role in the raise and development of a glaucoma process. The nervous system participation is another aspect to be considered in this disease. During the first decades of this century a link between the ocular tone and vegetative nervous system has been established. Beside this, rehabilitation treatment with relaxation techniques under sanatorial regimen had been introduced and thereby various factors had contributed to improve its treatment. 131 patients (251 eyes) with diagnosis of open primary angle glaucoma with ages between 20 to 79 years old, remained during 21 days in Escambray Kurthotel "Topes de Collantes", between January 1995 and October 1996. Visual function and ocular hydrodynamic had been studied in those patients, which were treated with ozone or ozone with magnetic field. Two subgroups had been created: one of then received local medical treatment with Timolol and the other without local treatment. Improvement in the visual functions as well as in ocular hydrodynamic were achieved. Mechanism of action is also reported.

 

OZONE THERAPY IN PATIENTS SUFFERING FROM OPTIC NERVE DYSFUNCTION.

R. Santiesteban, S. Menéndez1, M. Francisco, S. Luis.

One of the most frequent causes of blindness around the world is optic nerve dysfunction (OND), or optic atrophy, which can be the result of different disturbances affecting the visual pathway like ischemic, toxic, metabolic and hereditary-degenerative phenomena, injuries or compression, among others, producing this type of irreversible sequel. The ozone therapy is a very promising method to take into account. The main object of this study is to evaluate the feasibility to improve the visual function of a group of patients, with different degrees of OND with reduced possibilities of vision improvement, by means of ozone therapy. To 60 patients, suffering from OND of different etiologies and time of evolution, were applied the mixture ozone/oxygen endovenously by autohemotherapy, during 15 sessions. Ozone concentration and doses are used according to the biochemical status of each patient. An ophthalmological examination and a set of tests conformed by visual acuity (VA), visual field by Goldmann Perimetry (VF), visual evoked potentials (VEP), Pelli Robson Contrast Sensitivity Test (PRCST) was applied to patients before and after ozone therapy treatment. PRCST and VF were the parameters mostly improved in patients with 86 % and 83 % respectively, followed by VA (55 %) and VEP (37 %). Good results were achieved in all etiologies studied, except Leber optic atrophy, where no improvement was observed, neither objective nor subjective.

 

 

 

 

 

APPLICATION OF OZONE IN PATIENTS WITH KERATITIS.

J.C. Pina, Y. Mapolon1, M. Palma1, E. Recio1, C. Harrys1, M. Rodríguez1.

Since February 1996, 120 patients with keratitis were treated in the Retinitis Pigmentosa Center of Camagüey, Cuba. 60 patients (sample) were treated with ozone and 60 patients (control group) with conventional treatment (yodoxuridine, leuferon, homatropine, vitamin therapy). 35 males and 45 females, between 15 and 35 years old presenting photophobia and feeling of strange bodies in their eyes were evaluated. At the present, this disease has a long course and the conventional treatment is very expensive, mostly because of the medications it requires. The ozone treatment was rectal application and subconjunctival way, combining both. After the first week, all the patients treated with ozone started to show signs of improvement and they were totally cured after 3 weeks, while in the control group, the evolution had a long course, more than 6 months. We concluded that ozone therapy brings very positive results in the treatment of this disease.

 

AMBLYOPIA BY ANISOMETROPIA. A NEW THERAPEUTIC METHOD.

A. Torrado, R. Wong, G. Soto.

Thirty adult patients with the diagnosis of amblyopia by anisometropia were studied. The majority of the patients had high ametropia, predominantly myopia. Ozone therapy was used, associated to the usual treatment of visual exercises and macular stimulation. The use of ozone associated to traditional methods produced a better and more effective response in the recovery of the patient visual acuity, as well as shortening the treatment.

 

 

 

 

 

 

TREATMENT OF SENILE DEMENTIA OF ALZHEIMER TYPE WITH OZONE THERAPY AND ELECTROMAGNETIC FIELD.

J. J. Llibre, J. A. Samper, T. Laucerique, Z. Pérez.

The aim of this study was to introduce a new method of treatment by means of the combination of ozone therapy and electromagnetic field in the therapeutic of the Alzheimer disease, in order to improve the quality of life of these patients. This study was a prospective trial performed in 60 patients with probable Alzheimer's disease according to NINCDS-ADRDA group criteria. The evaluation of patients included clinical history, exploration of mental status according to Folstein's Minimental Test, Hachinski's isquemic score, the global deterioration scale and the dementia behavior score. Other studies included electroencephalograph, evocated potential (P300) and CT scan of the brain. The patients were randomly assigned in two treatment groups: Group I: rectal ozone and electromagnetic treatment and Group II: control group. Efficacy assessment was made at 3 months intervals and defined three ranges of responses: improvement, progression and not answer. Seventy-six percent of the patients who were treated with ozone and electromagnetic field improved after being treated during a month. This response remained in 57,0 % of the patients after six month of treatment. Any improvement was observed in the control group.

 

OZONE MEDICAL APPLICATION IN THE TREATMENT OF SENILE DEMENTIA.

M. M. Rodríguez, J. García, S. Menéndez1, E. Devesa, R. González2

In geriatrics, the concept of health is defined in terms of function, the healthy elderly is not that one, who lacks any pathology, but one who has the capacity to autonomy. Dementia is, probably, one of the most fearful diseases for the aging and worse-managed from the clinical point of view, which aggravates still more its prognosis, not only for the patient but also for the society in which he or she lives. This study is performed by means of the application of daily rectal ozone (20 sessions) to patients suffering from senile dementia (vascular, degenerative or mixed etiology), in doses according to the enzymatic status of each patient. All elderly persons that assisted to the Geriatric Department in Salvador Allende Hospital, during January/91 to February/95 were evaluated by clinical examination, psychometric tests, Hachinsky Scale, Katz index, Hamilton test (for depressive symptoms) and the Minimental Test (MMT) at the beginning

 

 

 

and at the end of the treatment. An important improvement was attained in the accomplishing of daily life activities, for all kind of dementia, with an enhancement in the quality of life. Any side effect was observed. This therapy is recommended in the treatment of senile dementia.

 

OZONE THERAPY IN DEMENTIAL SYNDROME IN THE ELDERLY.

M. Casas, B. Conde, M. Ornia, F. Ramos.

The aim of this paper is to evaluate the effectiveness of ozone therapy in demential syndrome, in the elderly, during two years. Clinical, neurophysiological and psicological evaluations, before and after ozone therapy, were performed and an evaluation criterion was defined. 30 patients were studied, 60 % represented the male sex and 40 % the female sex (70 % between 60 and 79 years old). According to the ethiology, Alzheimer dementia, multi-infarction dementia and vascular epilepsy were present. Improvement in 21 patients (70 %) was achieved, 7 patients (23 %) remained the same and 2 patients (7 %) got worse. It is recommended the generalization of this therapeutic protocol.

 

APPLICATION OF OZONE THERAPY IN ISCHEMIC CEREBROVASCULAR DISEASE.

M. M. Rodríguez, J. García, S. Menéndez1, E. Devesa, S. Valverde2.

The cerebrovascular disease is an actual health problem, because of the high tendency to produce sequels in those who survive, limiting their physical capacities and their social and familiar development. The objective of this study is to evaluate the effectiveness of ozone therapy in ischemic cerebrovascular disease, in acute, ancient and chronic phase. A group of patients, with this diagnose, that attend the Geriatric Service in Salvador Allende Hospital, during a period of 2 years were evaluated. Rectal ozone was daily administered, for a total of 20 sessions, in doses according to the enzymatic status. These patients were evaluated by clinical examination and their validity through the multidimensional evaluation method at the beginning and at the end of the treatment. Any antiaggregant medication was used, only physiotherapy

 

 

was associated. Better results were obtained in the acute phase. The initial clinical stage improved in more than 80 % of the total of patients treated. An increase in the quality of life was obtained.

 

OZONE THERAPY IN THE TREATMENT OF ELDERLY PATIENTS SUFFERING FROM PARKINSON'S SYNDROMES.

M. Rodríguez, J. R. García, S. Menéndez1, E. Devesa, A. Cámbara.

Parkinson's syndromes are present frequently in the third age, with a high tendency to produce disability. The aim of this paper is to study the effectiveness of ozone therapy in the improvement of the elderly autonomy, as well as the quality of life of patients suffering of Parkinson's disease, taking into account some therapeutical properties of ozone (increase of the antioxidant defense system, enhancement in the tissue oxygenation, metabolic modulation, improvement of the neuroplasticity phenomenom, etc.). A sample of 80 patients with Parkinson's syndromes of different nature were treated with rectal ozone (during 15 sessions) and physiotherapy. A complete neurologic and psychometric examination (Minimental test, Katz index, multidimensional evaluation, etc.) was performed in each patient, at the beginning and at the end of the treatment. The results demonstrated that all symptoms and signs studied improved after the treatment, fundamentally the rigidity (95.7 %), the gait (95.3 %) and the bradiphrasia (88.8 %). The Daily Life Activities improved in 95 % of the treated patients. Any side-effect or intolerance were observed during the treatment. In general, an improvement in the quality of life of these patients, increasing their autonomy for a much longer period was achieved.

 

ANALYSIS OF THE ELECTROPHYSIOLOGYCAL THRESHOLD, AUDIOMETRY AND LATENCY OF THE WAVE V IN CHILDREN WITH HEARING LOSS SUBMITTED TO OZONE THERAPY.

E. Basabe.

A double blind study, in Lina Odena special school for hearing loss, was performed. 34 children were selected with the same educational profile and divided at random in 2 groups: 17 received rectal oxygen and the others 17 received rectal ozone, in doses according to age. Comparing

 

the results, audiometry, electrophysiologycal threshold and the latency of the wave V to 90 DB, for the same ear, improved in a great percentage of children that received ozone therapy. Not the same behavior, with the children that received oxygen, was observed. It's concluded that ozone therapy is a valid method in the treatment of children with hearing loss.

 

HORMONAL PROFILE IN CHILDREN WITH HEARING LOSS THAT RECEIVE OZONE THERAPY.

E. Basabe, L. Bell1, R. Bell2, S. Menéndez3.

It was carried out a study in 19 children, of the special school "René Vilches" with different grades, ages and development level of language, with the aim of evaluating the behavior of different hormones (T4, T3, TSH, cortisol ) and insulin, at the beginning and at the end of rectal ozone treatment in doses according to weight. The results demonstrated that hiperthyroxinemia cases disappeared obtaining a value of T4 significantly lower in the post-treatment. Cortisol reached values significantly lower, up a normal population distribution. Also, insulin values were normal at the end of the treatment. This study showed that ozone, at appropriate doses, is capable to regulate the cellular metabolism.

 

PSYCOPEDAGOGICAL RESULTS IN THE SPECIAL SCHOOLS OF HEARING LOSS "RENE VILCHES" AND "LINA ODENA", AFTER 3 AND 5 YEARS OF OZONE THERAPY TREATMENT.

M. Miranda, G. Rodríguez1, E. Basabe2, S. Menéndez3, N. Sheshukova1, A. Soto1, M. Neyra1, X. García, M. Alarcón.

In this work it is shown the development in the scholar education of students with hearing loss of the special schools "René Vilches" and "Lina Odena". To this children different tests were applied in order to evaluate their evolution: reading test, development language, pronunciation,

 

sociability, attention and memory before the treatment of ozone therapy and after 3 and 5 years. In the investigation were selected a total of 49 children, in ages between 6 and 13 years old, each with their control group (without ozone treatment). For the experimental group, ozone was applied by rectal application, in doses according to age. The results demonstrated the improvement in the education process for the students treated with ozone therapy.

 

BASILAR VERTEBRA TRUNK DOPPLER OF PATIENTS WITH COCHLEO VESTIBULAR SYNDROME TREATED WITH THERAPY AND ACUPUNCTURE.

E. Basabe, V. Borroto1, L. Bell2, S. Menéndez3, C. López2, M. A. Alarcón4.

A study in 60 patients suffering of an incomplete cochleo vestibular syndrome with dizzy predominance, was performed. The patients were divided in 4 groups: 1-ozone, 2-ozone plus acupuncture, 3-acupunture and 4-medicaments. A basilar vertebra trunk doppler was made to each patients at the beginning, at the end of the treatment and after 6 and 12 months. The results demonstrated a significant improvement in the doppler (decrease of the peripheral resistance and spectral broadening-sb-) of those patients treated with ozone and ozone plus acupuncture in comparison with group 3 and 4. No significant difference, between group 1 and 2, was obtained. It is concluded that ozone therapy is an appropriate indication for this disease.

 

OZONE THERAPY IN SUPPURATIVE CHRONIC MIDDLE EAR DISEASE.

R. A. Durañona, S. Menéndez1, O. E. Rivero, A. Nieves.

The persistent inflammation of the middle ear adopt several forms owing to anatomical, physiological and bacterial factors. Patients with this disease suffer of continuos ears infections or relapses, presenting most of them a hearing loss, in relation with an injury in the sound-transmitting mechanism and a cochlear damage by toxicity or a direct propagation of the infectious process. The aim of this study is to evaluate the effectiveness of ozone therapy in

 

patients maintaining suppurative chronic middle ear disease after conventional medical treatment and regional surgery. A clinical trial was performed in 17 out-patients coming from external otorrhine office of Guevara Hospital and Mártires de las Tunas Hospital, between March and December/96. Patients received a cycle of treatment consistent in 15 sessions of rectal ozone applications, with an ozone concentration of 50 mg/L, and also installation of 2 drops of ozonized oil (OLEOZON) for 12 hours in each ear during 15 days. This cycle of treatment is repeated 3 months later. The results demonstrated that 16 patients (94 %, p<0.05) had negative bacteriological study at the end of the second cycle of treatment. Only in one patient remained septic conditions (pseudomones + proteus). The otoscopy showed 10 patients (59 %) with tympanic membranes completely recovered and in 7 patients still remained a little point without epithelization. According to audiometry, 14 patients (82 %, p<0.05) improved their hearing loss. Mastoid X-ray studies demonstrated improvement in 13 patients (76 %). It is concluded that ozone therapy is effective in the treatment of suppurative chronic middle ear, without any side effect.

 

THE USE OF OZONE THERAPY IN CRONIC PURULENT MESOTYMPANITIS.

V. Shakhov, A. Edeleva.

Conventional therapy of chronic purulent otitis media has been actual for a number of years. It is mainly aimed a control of inflammatory process in otitis media in chronic mesotympanitis, accompanied by marked mucositis. The existence of numerous methods of mucosites treatment proves these techniques to be of insufficient efficiency. Ozone is known to produce a marked effect on cellular metabolism when it is used in definite concentrations. It contributes to the elimination of intracellular hypoxia, activation of carbonic, fat and protein exchange, bringing synthetically, regeneratory and secretory functions of epithelial cell to normal level. Definite ozone concentrations produce bactericidal effect which is of no less importance in the course of chronic inflammatory process. We have developed an ozone therapy technique in controlling chronic mucositis of otitis media, based on ozone/oxygen irrigation of tympanic membrane and auditory tube mucous. 40 patients underwent a course of treatment that consisted of 7-10 daily procedures. Control group of 10 patients was on a conventional therapy. The results demonstrated that ozone therapy have no negative effect on internal ear or labyrinth function, even in prolonged applications of high ozone concentrations effecting mucous membrane of medial wall. Clinical effect was observed in inflammation control of mucous membrane, discharge reduction and restoration of auditory tube function. The use of ozone therapy in combination with complex therapy of chronic purulent mesotympanitis shortens the period of hospitalization. The developed method can be recommended as a stage during the preoperation preparation for myringoplasty.

 

OZONE THERAPY IN CHRONIC TONSILLITIS.

L. Silva, R. Wong.

The aim of this study is to evaluate the effectiveness of ozone therapy in patients with chronic tonsillitis. Two hundred and fifty patients received treatment with intratonsil ozone. Previously, tonsil biopsy (with fine needle) pharynx exudate, antistreptolysin O title, red count globes and sedimentation rate were performed at the beginning and at the end of ozone therapy treatment. Patient evolution continued until 1 year. According to the healing criterion satisfactory results were obtained; demonstrating the advantages of ozone therapy in the treatment of this disease.

 

OZONE THERAPY IN PATIENTS WITH DIABETIC NEUROANGIOPATHY. PRELIMINARY REPORT.

J. I. Fernández, S. Menéndez1, J. Turrent1, M. J. Colmenero2.

Diabetic neuroangiopathy is characterized by a symmetric abdormition, paresthesia and sometimes painful dysesthesia of the feet. Its evolution is slow, but it can produce a strength loss and an important alteration of the sensibility of the legs. Taking into account the advantages that ozone therapy exerts in diseases related with blood circulation disturbances and oxygen reactive species, as well as considering the effects of ozone as a stimulant agent of the antioxidant system and a metabolic regulator, the aim of this study is to evaluate rectal ozone therapy in patients suffering of diabetic neuroangiopathy in comparison with a control group using oxygen. Electrophysiologic studies of nervous conduction (amplitude and latency potentials for sensitive and motor conduction in peroneal and sural nerves, respectively, and nervous conduction rate), glycoside hemoglobin and glycemia in blood, at the beginning and at the end of the treatment were measured. Also, clinical was taking into account. The results demonstrated improvements, in the ozone group, in some of the electrophysiologic parameters measured (significant increase in the amplitude value of the proximal and distal peroneal nerve for both legs and for the nervous conduction rate), while any improvement was achieved in the oxygen group. Patients of both groups referred, in their autoevaluation, to feel better. Glycoside hemoglobin and glycemia pathologic initial values decrease significantly, up to normal values, after ozone treatment. Any side effect was observed.

 

 

 

THE USE OF OZONE THERAPY IN DISEASES OF PERIPHERAL NERVOUS SYSTEM.

Y. Potekhina, A. Gustov, S. Peretyagin, G. Dmitriev, E. Karpovich.

The treatment results of patients with diseases of peripheral nervous system are presented. 60 patients with ischemic neuropathias and 15 patients with diabetic polyneuropathy (age range 15-85 years) were treated at Ozone Therapy Department of Regional Diagnostic Center. They underwent a course of ozone therapy of dropping injections of ozonated saline and/or rectal insufflations of ozone/oxygen mixtures. 94 % patients had positive effect. No complications or side effect were noted. All the patients stated a significant reduction and in 60 % a complete disappearance of acroparesthesias and pains, having been the main complaint before the treatment. Tetrapolar rheography of extremities showed increase of pulse bloodfilling, moderate reduction of minor-vascular tension. One third of patients had changes in thermovision picture as local hyper -or hypothermia at the point of innervation of lesioned nerve. All the patients had a distinct positive dynamics as a diminished thermal difference with surrounding tissues and symmetric area. Electromyography revealed 5.6 m/sec increase of impulse rate along motor and sense fibers. Thus, ozone therapy is an effective method in treating diseases of peripheral nervous system, having ischemia in their genesis. Ozone can be administered as mono-ozone-therapy and in a complex treatment.

 

EFFECTIVENESS OF OZONE THERAPY IN THE PROCESS OF DIABETES'S TREATMENT.

E. Pavlovskaya, I. Sultanova, O. Maslennikov.

In 38 patients with diabetes were asked to express their opinion on the above treatment. There were 20 people of the 1st type of diabetes and 18 people of the 2nd one with different degrees of seriousness. The majority of sick people were in the state of decompensation, 22 people (57 %) of them were with some complications. The treatment was by means of intravenous drop injection of the ozone physiological solution and rectum injection O3/O2 of the mixture. The course consisted of 7-10 treatments. During the process of treatment the patients watched considerable improvement of their state: they stopped complaining of being thirsty, dry in a mouth, frequent urination, itch of the skin, numbness and tingling sensation in the tips of hands and feet, convulsions in calves of feet. The favorable mark during the first hours after the end of the treatment was lowering of glucose level of blood to 50 % in comparison with the primary figures before the treatment. At the end of the course glucose level of blood was lowered approximately up to 30 %. Besides, positive dynamics indexes of lipid spectrum, coagulagramme and immunogramme, rising of AOA of blood and lowering of the POL products

 

should be mentioned, in regard to the above treatment. The treatment helped the majority of the sick people to lower a dose of the insuline injected or sugarreduced preparations up to 30 %; in 47 % of cases to achieve compensation, and in 37 % of cases subcompensation of diabetes. The above observation shows that ozone therapy may be used in a complex treatment of people suffered of diabetes and allows to lower doses of the usage of sugar reduced preparations.

 

OZONE THERAPY IN CLINICAL PRACTICE.

O. Maslennikov, S. Budilin, D. Filatov.

The work presents the results of the treatment with ozone/oxygen mixtures at the Ozone Therapy Department of N. Novgorod Diagnostic Center for a two-year period. The treatment was performed with "Kvazar" ozonators. The followed patients had most common pathologies in clinical practice: atherosclerotic vessels -38.5 %, joints diseases -10 %, gastrointestinal disorders -20 %, diabetes mellitus -4 %. Ozone therapy was found to be highly effective. Positive results with double reduction of symptoms were received in 95 % patients with ischemic heart disease, 92 % with brain vessels disorders, 89 % with chronic gastritis, 80 % with gastric and duodenal ulcer, 86 % with osteoarthrosis deformans, 88 % patients with obliterating atherosclerosis of lower extremities could increase the painless walk distance in no less than 3 times. Hyperglycemia was reduced in all patients with diabetes mellitus. On the basis of clinical observations, bichemical, electro and echocardiography data, endoscopic and cytomorphologic tests there were developed treatment protocols in different diseases. Intravenous injections of ozonated solutions and rectal insufflations in atherosclerotic disorders; minor autohemotherapy, intestinal insufflations and peroral use of ozonated water and oil in gastro-intestinal diseases; intra-articular and subcutaneous infusions of ozone/oxygen mixtures in joints diseases were used. On the basis of long-term observations new programmes of preventive treatment with the use of ozone therapy are being developed for different nosological groups of patients.

 

OZONE THERAPY IN OBLITERATING ARTERIAL DISEASES OF LOWER EXTREMITIES.

V. Bolgov, I. Sultanova.

The work presents the results of ozone treatment of patients with obliterating vessels of lower extremities. 40 patients with obliterating atherosclerosis of lower extremities underwent ozone

 

therapy course. They were 38 male patients (age range 54-81) and 2 female patients of 60 and 73 years old. 28 patients had II-grade chronic arterial insufficiency, 12 patients had III-grade chronic arterial insufficiency. Obliteration was located in bilateral aorto-iliac segments (5), aorto-iliac segments with unilateral iliofemoral segments (5), bilateral iliofemoral segments (10), iliofemoral segments with unilateral tibial ones (12), femoral-popliteal segments with bilateral tibial ones (4), bilateral tibial segments (2), femoral-popliteal segment with bilateral tibial ones plus initial gangrene of toes (2). The patients received 8-12 procedures of intravenous infusions of ozonated saline (200 ml), minor autohemotherapy and stimulation of biologically active point when necessary. Highly effective was the procedure of external ozonation of lower extremities done in polyethylene sacs under increased pressure. Positive result was received in 93.8% of cases, 6.2% had no effect. The improvement could be seen in 3-5 procedures; the decrease of pain intensity in musculus gastrocnemius on walking, control of trophic changes, improvement of peripheral blood flow, increase of tolerance to physical exertion. The best results were achieved in patients with II-grade chronic arterial insufficiency, 2 patients had regression of initial gangrene of toes. Parenteral infusion of ozonated saline in combination with minor autohemotherapy, stimulation of bio-active point and external ozonation was shown to restore peripheral circulation and microcirculation. The experience of treating obliterating vessels of lower extremities with ozone proved its high efficiency.

 

CLINICAL EVALUATION OF A NEW OZONE THERAPY METHOD.

S. Alekhina, G. Pigalova, S. Peretyagin, C. Kontorschikova.

The aim of the work was to evaluate the efficiency of a new ozone therapy method - infusion of ozonated blood into biologically active points: 43/x+ -sya -si, 2./x11- sin -tzyan, 44/111 -nei -tik, 3/IV - tai - bai. These points were chosen due to their function, in Chinese medicine their stimulation brings the decrease of LP levels and normalization of microcirculatory bed indexes. The method was tested on 31 patients with II B-III stage of obliterating atherosclerosis of lower extremities. Every patient underwent 6-8 procedures with single ozone dose of 100 g. After the 1-2 procedures the patients stated they felt worse, while after the 3-4 procedures a positive dynamics was noted in the course of the disease, revealed in a longer walking distance, less leg-aches, improvement of lower extremity arteries pulse, increase of ankle index. Biochemical findings showed reduction in total cholesterol and -lipoproteins. Chemiluminescence of blood plasma demonstrated activation of general antioxidant blood system and weakened tendency to LP intensification. In comparison with control group, the infusion of ozonated blood into biologically active points produces a more profound stimulating affect than a traditional acupuncture. The observed ozone effect can be explained by activation of oxygen-dependent processes, including -oxidation of lipids. They lead to formation of macroergic ATP and NADH 2 molecules that are known to be protons donors to restore oxidised components of antioxidant

 

system. As a result it comes to normalization of LP processes, adhesive and aggregation erythrocytes and thrombocytes properties, improvement of rheological blood data. Thus, there has been proved the possibility to enlarge the range of low ozone concentrations to be infused in a form of ozonated blood into biologically active points.

 

TOTAL OZONE THERAPY OF TROPHIC ULCERS OF LOWER EXTREMITIES IN ELDERLY PATIENTS.

S. Gorbunov, L. Gorbunova, Ph. Romashov, V. Dmitriev, V. Isaev.

Trophic ulcers of foot and crus are known to be a common pathology among elderly patients causing frequent loss of working capacity and disability, requiring a long course of treatment and having a tendency to recurrence. The available current methods of treatment do not appear to be sufficient and effective enough. It gives rise to a search of new methods for their treatment. Local complex treatment, aimed a sanatory and stimulation of spontaneous epithelization, seems to be more appropriate for patients of elderly and gerontal age, having a lot of accompanied diseases. Hence, current treatment principles should be based on agents with marked antibacterial properties and simultaneously able to eliminate local hypoxia and regulate oxygen dependent processes. Medical ozone meets all these requirements. Regarding its medical properties, ozone has been used in the complex treatment of 42 patients with long-term trophic ulcers of foot and crus (age range 61-8~ years). Complex ozone therapy included local effect of gaseous ozone in plastic sac. Besides, for the first 8-10 days the ulcer was covered with ozone saturated antiseptic dressing. With the signs of marked epithelization, antiseptic dressing were substituted by the ones with ozonated olive oil. Ulcers with pyo-necrotic deposit were covered with ozonated enterosorbents for the first 3-5 days. Along with external treatment in plastic sacs, the surrounding surface of ulcer was subcutaneously injected with ozone/oxygen mixture. With the aim of detoxication, as well as normalization of oxygen-dependent processes and improvement of microcirculation, all the patients received intravenous injections of 250.0 mL ozonated rheopolyglukine, daily. The most efficient was found to be a complex treatment of vulnerosorbtion with press vacuum external ozone therapy in hard-frame chamber. By the 10 12 day of treatment the ulcer surface became sterile, epithelization rate being not more than 4-5 % a day, starting from the third week it reached 11-12 % a day. Only one patient, out of 42, did not have a complete cover of ulcerative defect in skin surface.

 

 

 

 

OZONE PLUS COBALT THERAPY IN PATIENTS SUFFERING FROM PROSTATIC CANCER.

L. Borrego, L. L. Borrero, E. C. Díaz1, S. Menéndez2, L. R. Borrego3, R. A. Borrego3.

Prostatic adenocarcinoma is the most frequent tumor in men older than 50 years old, representing the 16.7 % of all the death cases of cancer in male sex. With an early diagnose and an appropriate treatment the survival increase in 5 years, in 91 % of cases. Cancer metabolism is fundamentally anaerobic, for that reason, increasing oxygenation in damaged tissues, may diminished the side effects produced by radiation treatments, as well as increase radio-sensibility. The aim of this study is to evaluate the efficacy of ozone therapy in conjunction with cobalt-60 therapy, in the treatment of patients suffering from prostatic cancer, taking into account the influence that ozone exerts in tissue oxygenation. 70 patients with malignant neoplasia in prostate, stage A and B of the disease (intracapsular) were treated by an oncourology muldisciplinary group of the "Lenin" Hospital (Holguin Province). 35 patients were treated with rectal ozone plus cobalt therapy (ozone group) and 35 with cobalt therapy only (control group). The appearance of side effects (dermatitis radiation, cystitis, proctitis) and the behavior of some humoral and clinical parameters were evaluated up to 6 months after finishing the treatment. 84 % and 52 % of side effects were presented in control group and ozone group, respectively. Prostatic specific antigen (PSA) decrease, less than 10 ng/mL, in 92 % of patients treated with ozone and in 52 % in control group, one month after finishing the treatment. 88 % and 80 % of clinical and humoral control of the disease were obtained in ozone group and control group, respectively, 6 months later. It is concluded that, combining cobalt therapy with ozone, a decrease in side effects and an increase in radio-sensibility were achieved.

 

OZONE THERAPY IN THE TREATMENT OF PATIENTS WITH SECONDARY IMMUNODEFICIENCIES.

R. Puga, R. Rodríguez, C. González, J Muñoz.

Therapeutic effects of ozone therapy in 22 pediatric patients, with diagnosis of secondary immunodeficiencies (humoral and cellular), caused by recurrent episodes of acute respiratory infections from the upper and lower respiratory tract , were evaluated clinically and immunologically. Rectal ozone applications, with doses according to ages, was used in all

 

patients. After treatment, clinical improvements, decrease in the frequency of episodes and also immunological improvements in the parameters studied were achieved. We did not reported side- effects with the use of ozone therapy. New therapeutic possibilities are open for secondary immunodeficiencies treatment.

 

OZONE THERAPY IN PATIENTS WITH CHRONIC GASTRITIS.

S. Androsov, L. Eremina, N. Nikolaev, B. Sarantzev, O. Maslennikov.

The aim of this work was to assess the efficiency of ozone therapy in patients with chronic gastritis. There were treated 68 patients with different forms of chronic gastritis associated with Helicobacter pylori (CGV). Every patients underwent a complex of clinico-laboratory tests, endoscopic and cytomorphologic examination. Clinical effect was observed in 89% of cases, including improvement of endoscopic picture in 43 %, and histologically valid decrease of inflammatory activity with limitation of haemorrhages and normalization of microcirculation in gastric mucosa in 71 %. Helicopter pylori (HP) was controlled in 29% and HP dissemination was reduced in 23 %. The tension of local inmune gastric reactions was increased in 74 % of cases. 19 patients had minimal side effects that were controlled during the first 1-3 days of treatment. According to the accompanied pathology there were developed protocols of CGV differential treatment including peroral administration of ozonated water and ozonated oil, rectal insufflations of ozone/oxygen mixture, parenteral infusions of ozonated blood and ozonated liquids, acupuncture of biologically active points with ozone/oxygen mixture. Besides there were determined indications and counterindications to ozone therapy method, the range of necessary tests and efficiency criteria. Ozone therapy was found to be effective, non-medicament method of CGV treatment with good tolerance and easy to use.

 

DYNAMICS OF HISTAMINOPEXIA AND SEROTONINOPEXIA IN NEURODERMATIS PATIENTS DURING OZONE THERAPY.

O. Bitkina.

It is known that small doses of ozone lead to selective oxidation of the aminoacids. Sulfur contained and aromatic aminoacids are most sensitive to ozone activity. Particularly during ozone influence histidine (predecessor of histamine) level is decreasing. The increase of biogenous amines in the acute stage with heritable deficit of the plasmopexic fractions

 

(histaminopexia and serotoninopexia). Ozone therapy by means of minor autohemo-ozone therapy and rectal insuflactions was used for treating 60 neurodermatitis patients, 27 male and 33 female persons. Patients were from 9 to 35 years of age, 21.8 years in average. The disease lasted from 1 to 35 years ((18.7 years in average). The study of histaminopexic index (HPI) and serotoninopexic index (SPI) was made before ozone therapy course, the 2nd test was performed in 10 to 14 days of monoozone therapy and the 3rd test after the complex treatment which included traditional aids. 32 patients (53 %) demonstrated clinical remission, 27 (45 %) significant improvement and 1 patients (2 %) had small improvement. Initial HPI level is not significant high than control group data (19.49 ± 7.04 %, the normal is 16.4 ± 1.1 %). After 10-14 days of the monoozone therapy, HPI was increased to 30.33 ± 7.12 %. After the treatment HPI was decreased to 9.86 ± 3.69 %. Initial SPI level was 19.84 ± 1.59 % (the normal is 21.2 ± 2.8 %). In neurodermatitis, complicated by eczema, SPI level (13.49 ± 2.33 %) was significantly lower than in general group data (p-0.05). After 10-14 days of the monoozone therapy SPI was increased to 21.12 ± 1.59 %. After the complex treatment SPI was decreased to 18.26 ± 1.29 %. Generally SPI dynamics was like to HPI activity changes. During ozone treatment histaminopexic and serotoninopexic plasma activity increased. Decrease of that data after the treatment may be explained by elimination of connected histamine and serotonine from organism.

 

OZONE THERAPY IN ISCHEMIC HEART DISEASE (IHD).

Y. Shaarov, N. Maslennikova, N. Dushkina, O. Maslennikov.

The aim of the work was to study the efficiency of ozone therapy in IHD patients. There were treated 85 patients, 80 having stable II-III stenocardia, 5 patients had progressive angina pectoris. The treatment course was done in 3-4 weeks. Ozone/oxygen mixtures were administered in intraveous drops infusions and rectal insufflations. The patients condition was checked by clinical signs (number of stenocadial attacks and nitroglycerine use), tolerance to physical loads data, EKG readings, echocardioscopy. Positive results were received in 76 patients (of 80 patients with stable stenocardia -95 %) that were on ozone therapy. Attacks of stenocardial pains were completely controlled in 46 out of 80 patients (58%) with stable stenocardia. The amount of pain attacks was diminished in 50 % in 30 patients (37.5%). This enabled the patients to low the dose of nitrates and in a number of cases to discontinue their use. 4 patients (5 %) did not have any improvement in their condition. Ozone therapy proved to be highly effective in patients with progressive angina pectoris and resulted in elimination of non-stable condition with significant reduction of coronary insufficiency symptoms. All the patients showed the increase to domestic and dosed physical loads. Instrumental readings had positive dynamics. Hence, ozone therapy can be regarded as a highly efficient method of IHD treatment. Positive results are provided by ozone influence on antioxidant, coagulation and oxygen-transport systems.

 

OZONE THERAPY IN SUPRA-SEGMENTAL VEGETATIVE DISORDERS.

S. Kotov, A. Gustov, C. Kontorschikova.

Dropping intravenous infusions of ozonated saline (OS) were used in complex treatment of 106 patients (average age 26.5) with the syndrome of permanent-paroxysmal vegetative dystonia (mean duration of 3.6 years). The most common etiological causes were neurosis (20 %), after- effects of closed cranicerebral injuries (17 %), psychoemotional tense (16 %), hereditary-constitutional factors (14 %). Ozone therapy course included 5 procedures, administered every other day. Control group consisted of 24 patients that were on placebo treatment. 38 patients were treated with the use of double blind method. All patients were made complex dynamic examination. The results showed that dropping intravenous OS infusions increased the efficiency of complex therapy of patients with supra-segemental vegetative disorders, decreasing resistance to the performed therapy. OS vegetotropic action was found to depend on concentrations, OS with ozone concentration of 800 g/L of ozone/oxygen mixtures has vegeto modifying properties. It should be adminitered in chronic post-traumatic headaches, tense headaches with signs outlow complications, dysosmia impairment, cardialgias. OS infusions with ozone concentrations of 400 g/L of ozone/oxygen mixtures produce sympatholytic, trophotropic effect and are recommended in chronic and episodic tense headaches, panic attacks, high level of anxiety and heliometeodependence. Normalization of integral indexes of total cardiointerval variability and cardiac rhythm wave structure were regarded as efficiency criteria in ozone therapy of patients with supra-segmentary vegetative disorders. Increase of superoxide dismutase activitiy in blood was regarded as biochemical efficiency criterion. Not producing significant changes in the cerebral bloodflow. OS reduces the deficiency of peripheral vasoconstriction, improves vegetative activity and thermoregulation. OS lows down the tense grade in regulatory systems function and increases defence-adjustable capacities of vegetative nervous system. Steady normalization of vegetative tonus was observed in patients with prevalent sympathic tonus and unsteady vegetative tonus when received 5 dropping OS infusions. Patients with prevalent parasympathic tonus required repeated courses of ozone therapy to maintain the stable vegetative homeostasis.

 

OZONE INFLUENCE ON PRO-INFLAMMATORY PROCESS IN MAXILLO-FACIAL PART OF HEAD AND NECK.

E. Durnovo, I. Kinyapina, C. Kontorschikova.

The results of ozone therapy combined with traditional treatment of 50 patients with odontogenic

 

maxillofacial phlegmons are presented. Ozone was used in concentrations of 1300 g/L for intravenous injections of ozonated saline and in concentration of 4500 g/L and 2000 g/L for local dialysis of wounds and mouthwash with ozonated distilled water. A special group consisted of patients with severe saprogenous necrotic phlegmons. The lesions involved the neck and mediastinal organs. The surgical management of such patients often includes tracheostoma and dissection of mandibular muscles to provide a better wound drainage. The use of ozone resulted in wound clearance from purulent exudate and necrosis on the 3-4 day. The wound was shown to have activation of mononuclear phagocytes, reinforcement of mesenchymal proliferation with parallel intensive development of epithelium covering the wound surface. Starting from the first ozonated intravenous procedure the patients showed improvement in general condition, normalization of body temperature and laboratory blood data, activation of general antioxidant system and local immune resistance of oral cavity. As a result secondary sutures could be done on 7-8 day and in some cases even to suture the wounds completely. It helped to avoid disfiguring scars formation.

 

THE USE OF OZONE IN MEDICINE. CASUISTICAL ANALYSIS.

I. Jiménez, G. Aguiler, R. Moro, E. L. Torrez, P. Dominguez.

Properties which determine its industrial as well as medical use are given to ozone, allotropic variety of oxygen, characterized by triatomic molecules. Among its medical properties we can mention: antimicrobial, antiviral, antimicotic, improve the supply of oxygen to hipoxemically affected tissue areas and reactives oxygen metabolism capacities of cell, being very useful in the treatment of many pathologies. Furthermore, its satisfactory results and its low cost, in comparison with other terapeutic agents, justify also its application. Our study shows the casuistical analysis in 45.000 patients treated in the Ozone Therapy Department of the Provincial Hospital of Villa Clara, in a six year period, pointing out the different medical specialities and pathologies in which ozone was used as therapeutic agent alone or combined with other therapies and its efficacy.

 

 

 

 

 

 

THERAPEUTIC APPROACH WITH ALLOTROPIC OXYGEN INSUFLATION AND ACUPUNCTURE IN INFERTILITY AND IN F.I.V.E.T. A HYPOTHESIS.

G. Menaldo, M. Sodano, A. Meluzzi.

In the western world, 20 to 25 % of all couples in reproductive age appear to have reproductive problems In our fertility and F.I.V.E.T. Centrally, we deal with infertility problems both with allopathic and natural medicine, the latter having a global approach. The combination of both seems to avoid multiple pregnancies and syndrome of ovaric hyperstimulation. We designed therapeutic protocols which make use of acupuncture points in order to obtain an appropriate ovulation . The stimulation of 4MP, 30S, 4VC points, in the ninth day of the menstrual cycle, cause a better blood perfusion of uterus and a better endometrium trophism. The use of allotropic oxygen in F.I.V.E.T technique seems to bring definite advantages both for reducing FSH dosage administration and in better preparing the endometrium, improving thus the change of implantation and inidation, real problem of failure in F.I.V.E.T. Much interesting has taken place around the rectal insufflation of allotropic oxygen before embryo-transfer. It seems that from the first trials of these procedures of Global Medicine, without side effect, may bring better result. We are waiting to have a wider numbers of cases and to better study the biological and clinical researches.

 

CLINIC COMPARATIVE STUDY OF OZONE THERAPY AND METRONIDAZOL IN INTESTINAL AMEBIASIS.

J. Bustelo, G. Vega.

Amebiasis is a disease, generally characterized, by dysentery with diarrhea, weakness and prostration. Also, nausea, vomithing and pain may be present. The aim of this study is to evaluate the efficiency of rectal ozone treatment in children suffering with intestinal amebiasis. The diagnose was made by cysts or trophozoites of E. histolytica in stools. A control group using Metronidazol was used in order to compare both groups. Ozone therapy was useful in the treatment of intestinal amebiasis with 83.8 % of efficiency and only 0.55 % of adverse effects, better than the treatment with Metronidazol who gets 71.1 % of efficiency and 17.7 % of adverse effects.

 

 

 

 

OZONE THERAPY: AN USEFUL ALTERNATIVE ON VIRULENT HEPATITIS TREATMENT.

Y. Betancourt, J.M. Toledo, E. Recio1, A. Gómez, M. Rodríguez1, C. Harrys1, J. P. Pina2

A study with 80 patients suffering from A, B, C hepatitis, since August 1996, in "Octavio de la Concepción y de la Pedraja Hospital, Camagüey (Cuba) was performed. Patients, between 17 and 45 years old, were checked before in our laboratory, in order to verify the diagnoses of hepatitis. Conventional treatment (repose and diet prescripted) plus ozone therapy was applied to 40 patients, the other 40 patients only received conventional treatment. Ozone was administered, daily, by rectal way (dose = 10mg), for a total of 15 sessions. During the first week of treatment, remission of all the symptoms took place as well as the enlargement of the liver, improving their conditions and their appetite. All patients were totally cured at the end of the treatment. Under the conventional treatment these symptoms remain for more than 10 days and the totally cure was achieved approximately 6 moths later. Comparing these results we can say that ozone therapy is a suitable treatment against hepatitis, improving the patients health and the healing time of the disease.

 

SUBCUTANEOUS OZONE THERAPY IN THE TREATMENT OF SIMPLEX HERPES.

J. Delgado, R. Wong, C. P. Regalado1, A. Noriega.

Simplex herpes is a skin disease of viral etiology of difficult treatment because its recurrence, and its repeated out breaks, with lesion of erythema and vesicles, aggregated in clusters; and symptoms like burn and prurito. After the three first days, the virus penetrates into the groups of ganglious near the lesion. It makes very difficult the recovery with the traditional treatment, because of the frequent recurrence. The treatment with subcutaneous ozone has avoided the relapses with positive results. The research was made in a group of 84 patients with simplex herpes localized in the genitals, lips and gluteals. It has not been reported the antiviral effect of ozone in this pathology by a subcutaneous way . This make the treatment very new and safe.

 

 

 

OZONE THERAPY IN DERMATOSES: PYODERMA.

S.L. Krivatkin, E.V. Krivatkina.

Ozone is one of a new therapeutic agents being used in dermatology. In a recent test, 64 patients (41 men and 23 women aged 15-64) suffering from different forms of pyoderma (ecthyma-6, erysipelas-1, furunculosis-18, hidradenitis-2, impetigo-29 and sycosis barbae-8) received ozone therapy (OT). Two of its standard forms were applied: autohemotherapy minor (AHT min, intramuscular injections of 10 mL 02/03 mixture in 5 ml of autoblood) and techniques with the use of a plastic bag. As a source of 02/03 mixture the ozonizer was used. The concentration of ozone was 7-20 g/ml. Along with OT most of the patients used traditional ointments. Clinical recovery was achieved in 51 patients, considerable improvement in 10, improvement in 1 and no positive results in 2 patients. These data compared with the results of the previous traditional treatment (ex. systemic antibiotics) in the same 20 patients showed a better and quicker improvement in most of them. Ozone therapy was well tolerated. It is safe to say that among the advantages of OT there are good tolerance, as well as the possibility of use in patients with candidiasis and intolerance to antibiotics, absence of pathogen resistance and relative inexpensiveness. Howerver at this time, OT can not ensure quick results in severe pyoderma (ecthyma, etc.) when systemic antibiotics can. Thus ozone therapy is an effective, safe and inexpensive approach to the treatment of pyoderma, it is worthy to be used.

 

SATURED Hb AND pO2 INVIVO AND EXVIVO IN PATIENTS TREATED WITH OZONE THERAPY.

R. Wong, A. Noriega, Cuba.

A research was made in more than 100 patients who received treatment with the method of major autohemotherapy; In these patients the Hb saturation and the partial oxygen pressure were measured before the start of the treatment and an hours after the administration of ozonized blood. There were taken also samples of the extracorporal ozonized blood. The results were compared with the samples above mentioned. This research demonstrated that there is an important positive response, concerning gasometry, in those who received this therapy, as well as it is appreciated a great increase of tissue oxygenation. The results are shown by means of tables and graphies, including the results of extracorporal ozonization.

 

CORRELATION OF PLASMA INTERLEUKIN 1 LEVELS WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS WITH AND WITHOUT OZONE.

Z. Fahmy.

The mean plasma level of interleukin 1 beta was significantly higher in 51 patients with rheumatoid arthritis (RA) than in 21 rheumatoid arthritis patients treated with ozone, as control group of similar age in both groups. Plasma IL-1 beta correlated positively with Ritchie joint index, pain score, and erythrocyte sedimentation rate and correlated negatively with haemoglobin concentration. These results support the idea that IL-1 beta has a central role in the phatogenesis of RA and the ozone has influenced in the concentration level of IL-1 beta.

 

IMMUNOLOGICAL FINDINGS IN THE PERIPHERAL BLOOD AND IN THE SYNOVIAL FLUID AFTER INTRAARTICULAR OZONE INJECTIONS IN RHEUMATOID ARTHRITIS.

Z. Fahmy.

The aim of this pilot study is to find the influence that 02/03 exerts in the cytokines in peripheral blood and in synovial fluid. In this study we have two groups of classical rheumatoid arthritis. One group treated with 02/03 (major haemotherapy and intraarticular 02/03 injections), the other group without 02/03. We find there are significant changes with 02/03 (granulocytes and other cell population).

 

CLINICAL ASPECT OF 02/03 IN RHEUMATIC DISEASES.

Z. Fahmy.

Among the disorders collectively named as rheumatism, progressive chronic polyarthritis constitutes a great problem, not only as regards to the frequency of its occurrence (1-2 % of the population), but also as regards its most effective therapy. Apart from non-medication (or physical) therapy methods, long-term antirheumatics, or so called basis therapeutics, represent the only medicaments known to have effects on the pathological processes involved, going beyond a symptomatic influence, contrary to the non-steroid antirheumatics and the corticoids. In medical ozone research over the recent year, we have arrived at results with confirm the necessity for therapeutical application of an ozone-oxygene gas mixture, not only clinically, but also biochemically.

 

OUR EXPERIENCES IN THE USE OF OZONE THERAPY IN THE ELDERLY.

M. Casas, B. Conde, F. Ramos.

During five years (1991-1995) we have used ozone therapy in the treatment of different diseases that are present in the elderly, for example upper and lower respiratory infections, arthrosis, pneumonia, immunodeficiency. A statistical analysis showed improvement in more than 80 % of the treated patients. No side-effects or intolerance was present among the patients treated with ozone. It is concluded that ozone therapy is an important therapeutic option to be considered in geriatric patients.

 

OZONE THERAPY IN THE TREATMENT OF OSTEOARTHRITIS.

B. Conde, M. Casas, M. Delgado, F. Ramos.

We have been using ozone therapy, during 5 years, in 200 patients with different types of arthritis, for example: lumbar arthritis, generalized arthrosis, hiposteoarthritis, knee arthrosis. In our group of patients, 60 % female and 40 % of male were present (80 % with more than 40 years old). Three groups of treatment were considered: group I , using ozone therapy alone; group II, ozone therapy plus medication (antinflamatory and/or analgesics drugs) and group III, ozone therapy plus medication and physiotherapy. In general. 85 % of improvement was obtained.

 

OZONE THERAPY IN REACTIVE ARTHRITIS.

B. Conde, M. Casas, C. Martínez, F. Ramos.

We have used ozone therapy, like part of the treatment, of 30 patients suffering from reactive arthritis, in the last three years. No significant difference in sex distribution were present, with predominance in ages less than 45 years. Patients with reactive polyarthritis and Reiter Syndrome were included in our study. In 55 % of patients, reactive arthritis was consequence of upper respiratory sepsis. The clinical evaluation was satisfactory, with a fast improvement and without side-effects.

 

OZONE THERAPY IN THE TREATMENT OF BONE INFECTIONS.

J.C. Escarpanter.

It was done an investigation about the therapeutic effects of ozone therapy in the treatment of bone and articular infections, in patients suffering of these lesions, admitted to the Service of Orthopedic and Traumatology of the General Teaching Hospital " Comandante Pinares", San Cristobal, Pinar del Río. General treatment was performed using ozone rectal application and local ozone treatment and ozonized oil (OLEOZON). Ozone therapy directly into the septic bone was applied as a unique treatment or combined with antibioticotherapy, surgery of lesions, etc. Good results were obtained in a great percent of patients, but an outstanding improvement was seen in patients treated with ozone as the only therapeutic method. It was well accepted by patients and no side effects were observed. It was concluded recommending its application in the treatment of chronic infections of the osteomioarticular system.

 

A SOLUTION FOR POST-TRAUMATIC OSTEAL EXPOSITIONS: ASSOCIATION OF GREATER OMENTUM GRAFT WITH OZONE THERAPY.

J. C. Escarpanter.

Due to the frequency of injuries with postraumatic osteal exposition of the limbs, it is reported the use of greater omentum in association with ozone therapy, as a practical solution to correct these defects, with exposition of the fracture focus and in the presence or not of local infection. It is demonstrated that with the association of these methods, healing time may be shortened, due to the early appearance of granulation tissue, even on osteal surfaces and a decrease in the inflammatory signs in a septic medium, with no signs of biological rejection. Also, wasting material, anesthetics, drugs, and stay length may be saved, taking the graft from patients operated of puerperal ligatures, previous acceptation of donors and recipient. The graft implantation is performed with local anesthesia and there is no previous preparation of the injured patient. It is fixed with alternative sutures, its cost is very low and the patients feels highly satisfied. It is concluded that the association of greater omentum graft with ozone therapy offers a good alternative therapeutic in the treatment of this disease.

 

 

 

 

OXYGEN-OZONE THERAPY AND OMOTOXICOLOGY DRUG IN GONARTHROSIS.

L. Cursio, G.Menaldo.

Gonarthrosis is a disease found more frequently in females ranging 2.1. Some authors maintain that this degenerative arthropathy is the most common kind of arthrosis. It is normally a bilateral condition although at its outset it present monoarticular symptoms. Traumas, congenital malformations (like: genu-valgum and genu-varum) and circulatory affections and meniscus alterations are the most frequently found causes of this diseases. Symptoms: pain seems to be unrelated and spontaneous and it can increase when walking, but mostly when going downstairs; the joint movements are reduced and can be painful when pressure is applied to the inner side of the joint. We have looked for a combined treatment with oxygen-ozone on the acupuncture points and homotoxicology substances such as: cimicifuga, colocynthis, arnica, belladonna . A mixture of oxygen-ozone (15 mL in all), whose concentration was 30 (g/mL, has been injected into the inter-joint space and around it (periarticulation). The patient felt a slight burning sensation which disappeared few minutes after the injection. The homotoxicology substances were thus given: arnica and cimicifuga by us, colocynthis or colocynthis belladonna by subcutaneous route around the joint. The number of patients treated for this case study were 48, between 43 and 62 years of age. Symptoms improved rapidly (after only 3-4 treatments) and night pain was greatly reduced and so was the swelling with a return of joint functions. The total number of treatments for patients was from a minimum of 8 to a maximum of 15, being space twice weekly first and weekly afterwards. Only 5 patients did not have a satisfactory outcome, due to their lack of cooperation. It is concluded that although some patients did not have a total remission of the pain, nevertheless they had the great advantage of not having night pain anymore, a more confortable sleep, less swelling and improved joint movement.

 

OXYGEN OZONE AND COLOCYNTHIS-CIMIFUGA TREATMENT IN SLIPPED DISC.

L. Cursio, G.Menaldo.

Low back pain presents nowadays a very serious socio-economic problem. It seems that at least once in life, 65 % of people, taken randomly from the total population, complains of serious low back, which may be further complicated into leg pain (schialgia). For this study we considered hernia of the spinal column located in L4-L5, L5-S1, because this sites represent 90 % of all back bone hernias. Patients complain of a variety of symptoms: some having only a slight back ache in the lumbar region, others refering symptoms of serious pain, which extended to the leg, sometimes complicated by a loss of feelings sensation (paraesthesia) and hipotonic

 

muscles. This study comprised 73 patients. We used mixture of oxygen-ozone and colocynthis-cimicifuga injected intramuscularly around the vertebra. The mixture of 20 mL of oxygen-ozone was injected into four sites with 4 mL (total) of colocynthis-cimicifuga near vertebra l4-l5 and l5-s1, bilaterally. The pain felt after the injection, lasted only a few minutes, no side effect or complication was referred. In 57 patients pain totally disappeared and all symptoms and muscles tone returned to normal. In 16 patients the pain improved and symptoms were reduced, but non completely suppressed. We can say that despite 20 % of failure, 80 % of our patients was enthusiastic about the outcome, considering the small effort required of them.

 

THE USE OF OZONE FOR THE INTENSIFICATION AND OPTIMIZATION OF ORAL HYGIENE.

L. M. Lukinikh, S. Y. Kosjuga, Russia.

Oral professional hygiene plays a great role in the prophylaxis of caries and parodontium diseases. There are a lot of data about the dependence of dental and parodontium tissues on one hand and on the quality of oral hygiene care, on the other hand. The clinical observation have proved that the long term rational controlled oral hygiene in the background of professional hygiene gives essential prophylactic results and work out necessity to take care of teeth. The practice proves that apart from theoretical knowledge about the oral hygiene and manual habits of thorough teeth cleaning, it is important that each child and adult should have self-control criterion. The sense of teeth smoothness may be a criterion, it can be achieved only by professional teeth cleaning. Grinding and polishing of dental and filling surfaces are being done by special brushes and abrasives pastes, skelps with fine filling and rubber during 5 minutes by horizontal, vertical and round movements, till the sense of teeth smoothness is achieved, that further determines time, technique and quality of teeth cleaning at home. At present, ozonized distilled water (distilled water is borbotaged by ozone mixture with an ozone concentration of 2000 ug/L during 10 minutes) is widely used, for intensification and optimization of oral hygiene. It is being done by gargling with 100 ml of ozonized water per patient (3-5 passages with 20-30 mL each) during professional teeth cleaning stages. Ozonized water increases and improved the qualitative hygienic indexes, and quantitative soft dental deposit of microbial flore composition vividly testifying to it. This investigation allows us to give recommendation about the combined usage of ozone therapy and professional oral hygiene. They are considered to be the methods of effective influence on microbial oral landscape. They are the successful complement and do not produce negative effects on hard dental tissues and parodontium.

 

 

 

 

 

EXPERIENCES WITH OZONE THERAPY IN THE SUTTON DISEASE (PERIADENITIS MUCOUS NECROTICA RECURRENS). A CASE REPORT.

G. Legrá, J. Turrent1, S. Menéndez1, M. del C. Luis2.

Sutton disease (Periadenitis Mucous Necrotic Recurrent) is a rather rare pathological condition characterized by several ulceration of the mouth, very painful, to a tendency to relapse and with a retracted healing. Many factors are involucrated in the pathogenesis of this disease, but the immgical response is one of the main aspects considered in the evolution of the pathological process. It is presented a case of a 12-year-old age patient with diagnosis of Sutton disease with 5 years of evolution, without satisfactory results, after testing multiple therapeutic methods. The patient has been treated with ozone therapy by gas rectal insufflation (20 sessions) and local applications of ozonized sunflower oil (OLEOZON) during 2 years. Relapses decrease during the treatment and the healing of the ulcerous injuries was more rapid and scar retractions was not observed. It is made a wide review of the topic in order to justify the application of this therapeutic method. This is the first report using ozone therapy treatment in this disease.

 

A COMPARATIVE STUDY OF A BACTERICIDAL ACTIVITY OF OZONIZED SOLUTIONS DURING TREATMENT OF INFLAMMATORY DISEASES OF PARADONTIUM.

S. Sorokina, M. Zaslavskaja.

The problem of paradontium inflammatory diseases treatment is one of the most urgent problems in stomatology. In spite of an abundance of existing remedies and methods of treatment this problem is far from solution. It was noted periodontal pocket microflora accustomization to antibacterial preparations and allergic reactions and side effects to them. The importance of searching new remedies becomes evident. The use of ozonized solutions for complex treatment of inflammatory diseases of paradontium is of great interest. For microbiological experiment a single irrigation of pathological periodontal pockets with ozonized solutions (water, olive oil) was performed. The pocket contents before and after irrigation were inoculated on a blood agar. Microscopic specimens were prepared simultaneously. In 18-20 hours the grown colonies were counted. After comparison of the obtained results a substantial

 

 

antibacterial activity of ozonized solutions was revealed. Number of colonies before irrigation was 48.6 ± 5.1 and after irrigation it was 6.2 ± 0.3. the specimens show a significant decrease and qualitative changes of pathological pockets contents.

 

OZONE THERAPY AS A PART OF A COMPLEX TREATMENT OF A PARADONTIUM DISEASE.

S. Sorokina, L. Lukinych.

Gingivitis and periodontitis are characterized by a local hypoxia of tissues and also by various microbic florae with asporogenic microorganisms and facultative anaerobes predominancy. It was demonstrated that a plaque is a part of an oral cavity microflora, but an increase of a dental deposit thickness causes changes in oral cavity ecology and leads to an anaerobiosis increase. The ecology violation leads to gingivitis and paradontitis. In this connection an ozone therapy of the above mentioned diseases is a pathogenically sound treatment. The clinical approbation of various ozonized solutions has shown a good therapeutic effect. The solutions thanks to their oxidizing properties promote soft dental deposit, mucus, alimentary residues dissolution that is confirmed by hygienic index of Green-Vermillion. Before treatment this index was 2.8 and after treatment 1.2. Besides, a local ozone therapy shows pronounced anti-inflammatory effects on paradontium disease, that is also confirmed by PMA index. Before treatment this index was 23% for gingivitis, 30% for paradontitis of a light degree, 65% for paradontitis of a middle degree. At treatment stages using irrigation of periodontal pockets the PMA index varies substantially and decreases 2 times (18.29 accordingly). As a result of the treatment, a stomatorrhagia during gingivitis decreases or completely disappears. The volume of a gingival trevicular fluid decreases by 1.8 and 2 times accordingly. The given therapy method is an example of an effective effect on inflammatory process in paradontium. This treatment is well endured by patients and does not cause side effects and may be used in any stomatologic institution.

 

APPLICATION OF OZONIZED OIL IN THE TREATMENT OF ALVEOLITIS.

O. Cruz, S. Menéndez1, M. E. Martínez2, T. Clavera2.

Septical alveolitis or septical osteitis of the alveolar cavity, after extraction is the most frequent

 

and painful complication of exodontia. It can developed, at the third or fourth post surgical day and it is characterized by a deep pain and necrotic odor. The etiology of the alveolitis is unknown, but the following facts increase its incidence: traumatisms, infections, vascular supply decrease in the surrounding bone and general systemic conditions. The etiology can be related to an inappropriate nutrition of the clot formed in the alveolus. Thanks to the germicide action of OLEOZON, just as its oxygenant power, that favors the tissue regeneration, this ozonized oil was applied in the treatment of alveolitis. 100 adult patients, divided at random, in two groups of 50 patients, were studied. To all patients, before treatments, saline solution for removing all rest of necrotic clot and/or inappropriate contents, was gently irrigated into the alveolar cavity and carefully dried with sterile swabs. Experimental group was covered, daily, with OLEOZON. Control group was treated locally with Alvogil, also daily, in addition to oral antibiotics. Cured was made every 72 hours and as many medical inspection as they need. Healing criterion was done, taking into account, the formation of cicatrization tissue and pain relief. Diabetes Mellitus and traumatic extractions were the factors that more favor the alveolitis appearance. In patients treated with OLEOZON and Alvogil, 92 % and 58 % of cured patients, respectively, were achieved, in 2 or 3 visits, with statistical significant differences between them. In OLEOZON group, 8 % needed 4 to 6 visits in order to complete their treatment and with Alvogil the number of patients represented 42 % Patients treated with OLEOZON cured faster than the patients treated with Alvogil with statistical significant differences. OLEOZON was well tolerated by patients, without any side effect. OLEOZON can be considered as an effective medication in the alveolitis treatment.

 

APPLICATION OF OLEOZON IN THE TREATMENT OF SUBPROSTHESIS STOMATITIS.

L. Lemus, E. Ordaz, E. Rodríguez.

The aim of this study is to evaluate the efficacy of OLEOZON (ozonized sunflower oil) in the treatment of Subprosthesis Stomatitis. 122 patient suffering from this disease were treated on "Briones Montoto" Dental Clinic (Pinar del Rio province) between January to April of 1996. Patients were divided in 3 groups: group 1, 50 patients treated with OLEOZON, without their prosthetics device; group 2, 45 patients without their prosthesis and without OLEOZON treatment and group 3, 27 patients who maintained their prosthesis and received OLEOZON, independently of the stomatitis degree affection. The influence of different factors: age, sex and stomatitis degree affection was statistically analyzed, through contingency tables. The healing was total (100 %) in the first group and the time required was reduced from 43.1 (group 2) to 8.4 days, not detecting any adverse reactions. 89 % and 4 % of healing was obtained in group 2 and 3, respectively. It is concluded that the withdrawal of the prosthesis is a very important aspect to consider and that with OLEOZON applications the healing time is reduced significantly.

 

DYSCHROMIA TREATED WITH OLEOZON.

E. T. Castañeira, O. Cruz, S. Menéndez1.

A preliminary study was performed with the aim of evaluating the OLEOZON action in the whitening of teeth, when by one reason or another they have lost their natural color. The sample was of 30 patients, 15 patients treated with OLEOZON and 15 patients treated with the conventional method (sodium perborate and acetone). In this study the vital teeth with dyschromia were excluded, we only treated the not vital ones or those teeth submitted to a removal of pulp. The withening of teeth was reached from the fifth visit on using OLEOZON. The control group had a similar behavior, so we can state that OLEOZON substitutes sodium perborate and acetone in the treatment of dyschromia with satisfactory results.

 

OLEOZON IN GYNECOLOGY.

G. Morris, S. Menéndez1.

As it has been tested the germicide power, "OLEOZON" (ozonized sunflower oil) is widely used in gynecological processes of microbial cause. It was applied daily, during 7 days, in 320 patients with micotic or bacterial Vulvovaginitis. We demonstrated its efficiency comparing the effects of this new medicament with the conventional ones, such as "Trivagin", "Nistatine", (tables or cream) "Canesten" and Chloranphenicol ovules. We carried out vaginal exudate initially and post-treatment with successful results with the group of patients treated with "OLEOZON". Any side-effect was report.

APPLICATION OF OLEOZON IN THE HEMORRHOIDS.

G. Morris, S. Menéndez1.

The knowledgement of the results obtained with "OLEOZON" in the treatment of infectious-

 

inflammatory affections and the non existence in literature of its utilization (application or use) in anal affections, constitute the central and main reason for its application in 200 patients carrying symptomatic hemorrhoids, that came to our Clinic to be assisted in "Gynecology " or "Obstetrics". The quick disappearance of the symptoms, as well as the regression of the lesion, place "OLEOZON" within the effective therapy for this affection so frequent in our population.

 

THERAPY EFFECTS OF OZONIZED OIL (OLEOZON) IN THE TREATMENT OF GIARDIASIS.

F. Piñol, N. Cedeño, W. Díaz1.

Giardia lamblia is a cosmopolite protozoan that, nowadays, creates serious problems of health because of the amount of symptoms that accompany its infection. Fifty patients from 17 to 55 years old suffering of giardiasis were studied. The diagnosis was confirmed by duodenal gavage or stool. The patients received daily 2 capsules of OLEOZON of 1 mL each (one in the morning and one in the night) during 10 days. Afterwards, stop treatment for 1 week and repeat the cycle the same as the first one. As healing criterion, the absence of cysts or trophozoites of Giardia lamblia, in a sample of duodenal superficial tissue under endoscopic sight, was considered. The results demonstrated that there was 67 % of parasitologic healing and 85 % of improvement in the inflammatory process that accompanies this disease (gastritis, duodenitis).

 

OZONIZED OIL (OLEOZON) IN THE TREATMENT OF CHILDREN SUFFERING OF GIARDIASIS.

M.E. González, S. Menéndez1, N. Cedeño, G. Orvera, W. Díaz1.

In the last years, an alarming increase in giardiasis, according to different reports of the Health World Organization, was achieved. The clinic symptomatology of this infection goes from cyst asymptomatic excretion to persistent and severe diarrheas, that could produce a syndrome of bad absorption. 362 children, from 8 months to 14 years, with Giardia lamblia, were studied. The diagnosis of giardiasis was confirmed by fecal heces or duodenal gavage. OLEOZON was dosified by drops or capsules, according to age, twice per day during 10 days, for 2 cycles of treatment with 7 days interval without medication. Approximately, 10 days after finishing the second cycle of treatment, a duodenal gavage was performed. As healing criterion, the absence of cysts or trophozoites of Giardia lamblia in fecal heces and in duodenal gavage were considered. With the pattern of treatment proposed, 76 % of cured children and 89 % of clinical improvement (elimination of symptoms) in the remaining not cured patients were achieved.

 

TREATMENT OF PRIMARY PIODERMA WITH OZONIZED SUNFLOWER OIL.

R. Alvarez, S.Menéndez1, M.Peguera, J.Turrent1.

Taking into consideration the germicide properties of the ozonized sunflower oil (OLEOZON), it was decided to make an investigation in 80 children between 1 and 14 year old, with the main objective of evaluating the effectiveness of the OLEOZON in primary pyoderma, comparing this with Gentamycin cream. The investigation was carried out in areas of health of the general Teaching Hospital "Comandante Pinares ", San Cristobal , Pinar del Rio , lasting 6 months. Patients were randomly assigned to both group of treatment; experimental (using OLEOZON) and control (using Gentamyicin) .To all patients bacteriological studies were done, at the beginning and after 15 days of treatment. The results demonstrated that the most frequent isolated germ was the Streptococcus haemolytic of group A. Healing effectiveness after 15 days of treatment, was 68 % for the OLEOZON and 28 % in those patients where Gentamycin was used. No side effect were observed.

 

EXPERIENCES OF NINE YEARS USING OZONIZED OIL IN DERMATOLOGY.

L. Falcón, D. Simón, S. Menéndez1, S. Moya, E. Garbayo, W. Díaz1.

The ozonized oils of vegetal source constitute an appropriate method for the local therapy of several diseases. The interaction of ozone with these oils produce a mixture of chemical compounds (ozonides and peroxides) with a great germicide power. The results of topical applications of ozonized oil (Oleozon) in dermatological diseases of viral, fungal and bacterial origin, during 9 years of study, were presented. Among the diseases of bacterial origin (for example, pyoderma), 600 patients were treated, obtaining a healing criterion in 87 %. According to mycotic diseases (for example, epidermophytosis, onychomycosis, etc), 1000 patients received the treatment, with 91 % of healing. In viral diseases (for example, herpes simplex), 300 patients were treated and in 72 % the relapses disappeared. Any side effect was observed.